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KMID : 0882420070720000322
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Korean Journal of Medicine
2007 Volume.72 No. 0 p.322 ~ p.326
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Development of acute myeloid leukemia during the treatment of non-Hodgkin’s lymphoma
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Pack Yun-Jung
Park Hoon-Suk
Eom Ki-Seong
Kim Young-Sin
Kim Hee-Je
Min Woo-Sung
Kim Choon-Choo
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Abstract
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The widespread use of intensive combination chemotherapy with/without radiation therapy has enhanced the long-term survival of the cancer patient. However, cytotoxic therapy has led to the emergence of late-complications, such as therapy-related acute myeloid leukemia (t-AML). We experienced a case of t-AML with inv(16) and the subsequent development of the t(9;22) abnormality. This is the first report of the coexistence of these abnormalities in t-AML. A forty-eight year old woman was diagnosed as having t-AML during treatment of low-grade non-Hodgkin’s lymphoma. The patient showed pancytopenia 10 months after the initiation of chemotherapy with a topoisomerase II inhibitor. After the patient achieved complete remission, she received allogeneic hematopoietic stem cell transplantation from a sibling, and has since been in excellent clinical condition. During a follow-up of patients treated for primary malignancies, the possibility of t-AML arising should always be considered. Not only a morphologic evaluation but also a cytogenetic study is necessary to study pancytopenia that may follow chemotherapy.(Korean J Med 72:S322-S326, 2007)
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KEYWORD
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t-AML, Non-Hodgkin’s lymphoma, Stem cell transplantation, Inv(16) and (9, 22)
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